Format

Send to

Choose Destination
J Thorac Oncol. 2016 Oct;11(10):1793-7. doi: 10.1016/j.jtho.2016.06.017. Epub 2016 Jul 25.

Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC.

Author information

1
Manchester Thoracic Oncology Centre, North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom; Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom. Electronic address: philip.crosbie@manchester.ac.uk.
2
Manchester Thoracic Oncology Centre, North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom; Department of Thoracic Surgery, University Hospital of South Manchester, Manchester, United Kingdom.
3
Manchester Thoracic Oncology Centre, North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom; Department of Thoracic Surgery, University Hospital of South Manchester, Manchester, United Kingdom.
4
Institute of Cancer Sciences, University of Manchester, United Kingdom.
5
Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom.
6
Manchester Thoracic Oncology Centre, North West Lung Centre, University Hospital of South Manchester, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom.
7
Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom; Institute of Cancer Sciences, University of Manchester, United Kingdom; Department of Medical Oncology, The Christie National Health Service Foundation Trust, Manchester, United Kingdom.

Abstract

Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch) at the time of NSCLC surgery better identifies those patients at higher risk for lung cancer recurrence than does peripheral circulating tumor cell number alone.

KEYWORDS:

Circulating tumor cells; Early stage; NSCLC; Recurrence; Surgery

PMID:
27468936
PMCID:
PMC5063509
DOI:
10.1016/j.jtho.2016.06.017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center