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Springerplus. 2016 Jul 16;5(1):1103. doi: 10.1186/s40064-016-2794-0. eCollection 2016.

Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.

Author information

1
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan.
2
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi Japan.
3
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan ; Department of Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan.

Abstract

PURPOSE:

The aim of this study is to investigate the relationship between arterial pulse amplitude change under increased shear stress and the presence of ischemic heart disease (IHD).

METHODS:

This study comprised 31 subjects, including 14 subjects with IHD. We investigated the change in brachial artery pulse amplitude during flow-mediated dilation (FMD) using ultrasonography.

RESULTS:

The arterial pulse amplitude increased during FMD in 19 subjects, whereas it decreased in 12 subjects. There was a marked difference in the change in arterial pulse amplitude (the maximum amplitude of the arterial pulse amplitude during FMD/the arterial pulse amplitude at baseline) between subjects with and without IHD (0.98 ± 0.53 and 1.37 ± 0.53, p = 0.028). Furthermore, decreased arterial pulse amplitude during FMD was a significant predictor of IHD after adjustment of age, blood pressure, the presence of each type of coronary risks, the value of FMD and sex (p = 0.0001).

CONCLUSIONS:

The decrease of arterial pulsation amplitude during FMD was a useful predictive parameter for IHD.

KEYWORDS:

Arterial pulsation; Flow-mediated dilation; Ischemic heart disease; Vascular ultrasound

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