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Mol Nutr Food Res. 2016 Dec;60(12):2642-2653. doi: 10.1002/mnfr.201600170. Epub 2016 Sep 15.

Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people.

Author information

1
Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, USA.
2
Department of Pediatrics, Section of Neonatology, University of Colorado Denver, Aurora, CO, USA.
3
Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
4
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
5
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
6
Department of Nutrition, University of California, Davis, CA, USA.
7
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
8
Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
9
Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, USA.
10
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

Abstract

SCOPE:

n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity; however, the mechanisms of protection remain poorly characterized. The stearoyl CoA desaturase (SCD), insulin-sensitive glucose transporter (SLC2A4), and sterol regulatory element binding protein (SREBF1) genes are transcriptionally regulated by n-3 PUFA intake and harbor polymorphisms associated with obesity. The present study investigated how consumption of n-3 PUFA modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes.

MATERIALS AND METHODS:

Anthropometric variables and metabolic phenotypes were measured in a cross-sectional sample of Yup'ik individuals (n = 1135) and 33 polymorphisms were tested for main effects and interactions using linear models that account for familial correlations. n-3 PUFA intake was estimated using red blood cell nitrogen stable isotope ratios. SCD polymorphisms were associated with ApoA1 concentration and n-3 PUFA interactions with SCD polymorphisms were associated with reduced fasting cholesterol levels and waist-to-hip ratio. SLC2A4 polymorphisms were associated with hip circumference, high-density lipoprotein and ApoA1 concentrations. SREBF1 polymorphisms were associated with low-density lipoprotein and HOMA-IR and n-3 PUFA interactions were associated with reduced fasting insulin and HOMA-IR levels.

CONCLUSION:

The results suggest that an individual's genotype may interact with dietary n-3 PUFAs in ways that are associated with protection from obesity-related diseases in Yup'ik people.

KEYWORDS:

Alaska Native; BMI; Gene-by-environment interactions; n-3 PUFA

PMID:
27467133
PMCID:
PMC5148654
DOI:
10.1002/mnfr.201600170
[Indexed for MEDLINE]
Free PMC Article

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