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Head Neck. 2016 Dec;38(12):1739-1751. doi: 10.1002/hed.24532. Epub 2016 Jul 28.

Long-term outcomes after multidisciplinary management of T3 laryngeal squamous cell carcinomas: Improved functional outcomes and survival with modern therapeutic approaches.

Author information

1
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
3
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
4
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
5
Department of Radiation Oncology, Sisli Etfal Teaching and Research Hospital, Istanbul, Turkey.
6
Department of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.
7
Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Erratum in

Abstract

BACKGROUND:

The purpose of this study was to evaluate the long-term outcomes after initial definitive or adjuvant radiotherapy (RT) for T3 laryngeal cancers.

METHODS:

We reviewed 412 patients treated for T3 laryngeal squamous cell cancer from 1985 to 2011.

RESULTS:

The 10-year overall survival (OS) was 35%; disease-specific-survival (DSS) was 61%; locoregional control was 76%; and freedom from distant metastasis was 83%. Chemotherapy, age, performance status <2, node-negative status, and glottic subsite were associated with improved survival (all p < .03). Larynx preservation with induction and/or concurrent chemoradiotherapy (LP-CRT) had better laryngectomy-free survival than RT alone (LP-RT; hazard ratio [HR] = 0.62; 95% confidence interval [CI] = 0.47-0.81; p = .0005); 10-year laryngectomy-free survival rates of the LP-CRT cohort (37%) were higher than those of the LP-RT cohort (18%). The 5-year DSS and OS rates of the LP-CRT cohort (79% and 67%) were better after total laryngectomy with postoperative RT (TL-PORT; 61% and 50%) and LP-RT (64% and 46%; p < .006 for all).

CONCLUSION:

In patients with T3 laryngeal cancers, LP-CRT provides better functional, oncologic, and survival outcomes than historical TL-PORT or LP-RT does. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1739-1751, 2016.

KEYWORDS:

T3; outcomes; radiotherapy; survival; total laryngectomy

PMID:
27466789
PMCID:
PMC5539952
DOI:
10.1002/hed.24532
[Indexed for MEDLINE]
Free PMC Article

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