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Anticancer Res. 2016 Aug;36(8):4273-8.

Long-term Survival After Surgical Treatment of Renal Cell Carcinoma Metastasis Within the Pancreas.

Author information

1
Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany panagiotis.fikatas@charite.de.
2
Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.

Abstract

BACKGROUND:

The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear.

PATIENTS AND METHODS:

In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014.

RESULTS:

Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome.

CONCLUSION:

The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma.

KEYWORDS:

Renal cell carcinoma; metastasis; pancreas; survival

PMID:
27466543
[Indexed for MEDLINE]

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