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Anticancer Res. 2016 Aug;36(8):4039-44.

DNA Repair Gene Expression Levels as Indicators of Breast Cancer in the Breast Cancer Family Registry.

Author information

1
Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, U.S.A. maya.kappil@mssm.edu.
2
Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, U.S.A.
3
Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, U.S.A. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, U.S.A.
4
Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, U.S.A. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, U.S.A.

Abstract

AIM:

The expression level of DNA repair-related genes and their association with breast cancer status among participants of the New York site of the Breast Cancer Family Registry was investigated.

MATERIALS AND METHODS:

RNA from mononuclear cells in 194 sister sets (n=475 women) were assayed for ATM, BRCA1, MSH2, MUTYH and XPC gene expression levels and analyzed using generalized estimating equations (GEE).

RESULTS:

Individuals with decreased ATM and MSH2 expression had significantly higher odds for breast cancer compared to individuals with higher levels of expression (odds ratio (OR)=1.1, 95% confidence interval (CI)=1.02, 1.18) and (OR=1.90, 95% CI=1.21, 2.97), respectively. Upon stratifying the GEE model, reductions in ATM and MSH2 expression levels was heightened among women with an extended family history (FH) of breast cancer.

CONCLUSION:

Reduced expression of ATM and MSH2 compromises DNA repair capacity and, thereby, increases breast cancer prevalence.

KEYWORDS:

Breast cancer; DNA repair; family history; gene expression

PMID:
27466510
PMCID:
PMC5278521
[Indexed for MEDLINE]
Free PMC Article

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