Format

Send to

Choose Destination
Clin Vaccine Immunol. 2016 Sep 6;23(9):795-9. doi: 10.1128/CVI.00088-16. Print 2016 Sep.

Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

Author information

1
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
2
Mapp Biopharmaceutical, Inc., San Diego, California, USA.
3
Mapp Biopharmaceutical, Inc., San Diego, California, USA larry.zeitlin@mappbio.com nicholas.mantis@health.ny.gov.
4
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA larry.zeitlin@mappbio.com nicholas.mantis@health.ny.gov.

Abstract

PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potent in vitro and in vivo toxin-neutralizing activities. We also report the minimum serum concentrations of hPB10 required to protect mice against 10 times the 50% lethal dose of ricin when delivered by injection and inhalation.

PMID:
27466351
PMCID:
PMC5014922
DOI:
10.1128/CVI.00088-16
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center