Format

Send to

Choose Destination
Int J Immunopathol Pharmacol. 2016 Dec;29(4):734-741. Epub 2016 Jul 27.

Curcumin ameliorates insulin signalling pathway in brain of Alzheimer's disease transgenic mice.

Feng HL1,2, Dang HZ1,3, Fan H1,4, Chen XP1,5, Rao YX6, Ren Y1,2, Yang JD1,2, Shi J1,7, Wang PW8,2, Tian JZ1,7.

Author information

1
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine (BUCM), PR China.
2
Key Laboratory of Pharmacology of State Administration of Traditional Chinese Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine (BUCM), Beijing, PR China.
3
Pneumology Department, Huimin Hospital, Beijing, PR China.
4
Beijing Chaoyang Combine Traditional Chinese and Western Medicine Emergency Medical Center, Beijing, PR China.
5
Kaifeng Hospital of Traditional Chinese Medicine, Kaifeng, PR China.
6
University of Washington, Seattle, WA, USA.
7
BUCM Neurology Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, PR China.
8
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine (BUCM), PR China pw_wang@163.com.

Abstract

Deficits in glucose, impaired insulin signalling and brain insulin resistance are common in the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce the amyloid pathology in AD. Moreover, it is a well-known fact that curcumin has anti-oxidant and anti-inflammatory properties. However, whether or not curcumin could regulate the insulin signal transduction pathway in AD remains unclear. In this study, we used APPswe/PS1dE9 double transgenic mice as the AD model to investigate the mechanisms and the effects of curcumin on AD. Immunohistochemical (IHC) staining and a western blot analysis were used to test the major proteins in the insulin signal transduction pathway. After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased. Among the curcumin groups, the medium-dose group was the most effective one. Thus, we believe that curcumin may be a potential therapeutic agent that can regulate the critical molecules in brain insulin signalling pathways. Furthermore, curcumin could be adopted as one of the AD treatments to improve a patient's learning and memory ability.

KEYWORDS:

APPswe/PS1dE9 double transgenic mice; Alzheimer’s disease; curcumin; insulin receptor; insulin signal transduction pathway

PMID:
27466310
PMCID:
PMC5806850
DOI:
10.1177/0394632016659494
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center