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Nat Rev Neurosci. 2016 Sep;17(9):550-61. doi: 10.1038/nrn.2016.86. Epub 2016 Jul 28.

Adhesion G protein-coupled receptors in nervous system development and disease.

Author information

1
Department of Neurophysiology, Institute of Physiology, University of Würzburg, Röntgenring 9, 97070 Würzburg, Germany.
2
Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
3
Department of Developmental Biology and Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA.

Abstract

Members of the adhesion G protein-coupled receptor (aGPCR) class have emerged as crucial regulators of nervous system development, with important implications for human health and disease. In this Review, we discuss the current understanding of aGPCR functions during key steps in neural development, including cortical patterning, dendrite and synapse formation, and myelination. We focus on aGPCR modulation of cell-cell and cell-matrix interactions and signalling to control these varied aspects of neural development, and we discuss how impaired aGPCR function leads to neurological disease. We further highlight the emerging hypothesis that aGPCRs can be mechanically activated and the implications of this property in the nervous system.

PMID:
27466150
DOI:
10.1038/nrn.2016.86
[Indexed for MEDLINE]

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