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Influenza Other Respir Viruses. 2016 Nov;10(6):536-539. doi: 10.1111/irv.12418. Epub 2016 Aug 9.

Assessment of antigenic difference of equine influenza virus strains by challenge study in horses.

Author information

1
Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan. yamanaka@equinst.go.jp.
2
Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.
3
Virology Unit, Irish Equine Centre, Johnstown, Naas, Co. Kildare, Ireland.

Abstract

We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11. The durations of pyrexia (≥38.5°C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP93 group.

KEYWORDS:

H3N8; challenge study; equine influenza; inactivated whole vaccine

PMID:
27465864
PMCID:
PMC5059955
DOI:
10.1111/irv.12418
[Indexed for MEDLINE]
Free PMC Article

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