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Am J Clin Nutr. 2016 Sep;104(3):837-43. doi: 10.3945/ajcn.116.132761. Epub 2016 Jul 27.

Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial.

Author information

1
Departments of Food Science.
2
Statistics.
3
Nutrition Science, and.
4
Physics and Astronomy, Purdue University, West Lafayette, IN; and.
5
Department of Medicine, Indiana University, Indianapolis, IN.
6
Nutrition Science, and weavercm@purdue.edu.

Abstract

BACKGROUND:

Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models.

OBJECTIVE:

In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women.

DESIGN:

We used our novel technology of determining bone calcium retention by following the urinary appearance of (41)Ca, a rare long-lived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomized-order, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d.

RESULTS:

A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P < 0.05) and 7% (P < 0.04), respectively. The bone turnover biomarkers N-terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035).

CONCLUSION:

Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947.

KEYWORDS:

41Ca; bone calcium retention; bone-specific alkaline phosphatase; postmenopausal women; soluble corn fiber

PMID:
27465372
DOI:
10.3945/ajcn.116.132761
[Indexed for MEDLINE]

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