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J Autism Dev Disord. 2016 Oct;46(10):3369-76. doi: 10.1007/s10803-016-2877-3.

Brief Report: The Prevalence of Neurofibromatosis Type 1 among Children with Autism Spectrum Disorder Identified by the Autism and Developmental Disabilities Monitoring Network.

Author information

1
Utah Autism Research Program, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108, USA. deborah.bilder@hsc.utah.edu.
2
Utah Autism Research Program, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108, USA.
3
Division of Medical Genetics, University of Utah, Salt Lake City, UT, USA.
4
Division of Medical Genetics, Stanford University, California, USA.
5
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
6
Department of Pediatrics, University of Arizona, Tucson, AZ, USA.
7
Division of Medical Genetics, Weill Cornell Medical College, New York, USA.
8
National Center on Birth Defects and Developmental Disabilities, Center for Disease Control and Prevention, Atlanta, GA, USA.
9
Department of Psychiatry, University of Utah, Salt Lake City, UT, USA.

Abstract

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). The frequency of ASD/NF1 co-occurrence has been subject to debate since the 1980s. This relationship was investigated in a large population-based sample of 8-year-old children identified with ASD (N = 12,271) by the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring (ADDM) Network. Twenty-two (1-in-558) children with ASD had diagnosed NF1, exceeding NF1 general population estimates by four to five fold. Children with ASD/NF1 versus ASD without NF1 were significantly less likely to receive a community-based ASD diagnosis (p = 0.04) and understand non-verbal communication (p = 0.001). These findings underscore the importance of including social-communication ability among relevant developmental concerns in children with NF1.

KEYWORDS:

Autism; Children; Developmental disabilities; Neurofibromatosis; Non-verbal communications

PMID:
27465244
PMCID:
PMC5494711
DOI:
10.1007/s10803-016-2877-3
[Indexed for MEDLINE]
Free PMC Article

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