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Neurol Sci. 2016 Nov;37(11):1853-1855. Epub 2016 Jul 27.

Rapidly progressive neurological deterioration in anti-AMPA receptor encephalitis with additional CRMP5 antibodies.

Author information

1
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China.
2
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, 450052, Henan, China. sunshilei18@163.com.

Abstract

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis positive for additional onconeural antibodies is rarely reported. Here we report the clinical features of a patient who developed limbic encephalitis with both glutamate receptor 2 (GluR2) and collapsin response mediator protein 5 (CRMP5) antibodies. Brain magnetic resonance imaging revealed multifocal encephalopathy. Chest computed tomography showed a highly suspicious malignant thymoma. He experienced rapid neurological deterioration during hospitalization. This report indicates that the clinical diversity of anti-AMPAR encephalitis and the presence of onconeural antibodies may lead to poor prognosis.

KEYWORDS:

AMPAR; Antibodies; Autoimmune; CRMP5; Encephalitis; Thymoma

PMID:
27465029
DOI:
10.1007/s10072-016-2680-0
[Indexed for MEDLINE]

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