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Toxicol Mech Methods. 2016 Sep;26(7):538-543. Epub 2016 Jul 27.

Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury.

Author information

1
a Department of Biomedical Sciences, Pharmacology Division, College of Medicine , King Faisal University , Al-Ahsa , Saudi Arabia.
2
b Department of Internal Medicine, College of Medicine , King Faisal University , Al-Ahsa , Saudi Arabia.
3
c Department of Biomedical Sciences, Histopathology Division, College of Medicine , King Faisal University , Al-Ahsa , Saudi Arabia.

Abstract

The potential nephroprotection of punicalagin (PNG) against lipopolysaccharide (LPS)-induced acute kidney injury in rats was investigated. Rats received a single i.v. dose of LPS (5 mg/kg), and treated with PNG (50 mg/kg, i.p.), 1 h before, and 1 h following LPS administration. LPS caused significant increases of serum creatinine and neutrophil gelatinase-associated lipocalin. LPS also resulted in significant increases in interleukin-18, tumor necrosis factor-α, interleukin-6, malondialdehyde, nitric oxide, Bax/Bcl-2 ratio and myeloperoxidase, inducible nitric oxide synthase, caspases 3, 8 and 9 activities, and a significant decrease in total antioxidant capacity in kidney tissues. PNG significantly ameliorated the alterations in the measured parameters. Additionally, PNG attenuated the histopathological injury and reduced kidney injury molecule-1 expression in kidneys of rats that received LPS. It was concluded that PNG ameliorated endotoxemic acute kidney injury in rats by counteracting inflammation, oxidative/nitrative stress and apoptosis.

KEYWORDS:

Endotoxemia; kidney; punicalagin; rats

PMID:
27464552
DOI:
10.1080/15376516.2016.1211207
[Indexed for MEDLINE]

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