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Sci Rep. 2016 Jul 28;6:30588. doi: 10.1038/srep30588.

Neural markers of social and monetary rewards in children with Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

Author information

1
Instituto de Neurociencia Cognitiva y Traslacional (INCYT), Laboratorio de Psicología Experimental y Neurociencias (LPEN), Fundación INECO, Universidad Favaloro, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
2
Universidad Di Tella. Buenos Aires, Argentina.
3
Programa Argentino para Niños, Adolescentes y Adultos con Condiciones del Espectro Autista (PANAACEA), Buenos Aires, Argentina.
4
Centre for the Study of Argumentation and Reasoning, Faculty of Psychology, Universidad Diego Portales, Santiago, Chile.
5
Laboratorio de Neurociencia Cognitiva y Social (LaNCyS), Facultad de Psicología, Universidad Diego Portales, Santiago, Chile.
6
Laboratorio de Neuroimágenes, Universidad Nacional de Córdoba, Argentina.
7
Grupo de Neurociencia Cognitiva, Universidad de Granada, España.
8
Centre of Excellence in Cognition and its Disorders, Australian Research Council (ACR), New South Wales, Australia.
9
Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibanez, Santiago de Chile, Chile.
10
Universidad Autonoma del Caribe, Barranquilla, Colombia.

Abstract

Recent theories of decision making propose a shared value-related brain mechanism for encoding monetary and social rewards. We tested this model in children with Attention-Deficit/Hyperactivity Disorder (ADHD), children with Autism Spectrum Disorder (ASD) and control children. We monitored participants' brain dynamics using high density-electroencephalography while they played a monetary and social reward tasks. Control children exhibited a feedback Error-Related Negativity (fERN) modulation and Anterior Cingulate Cortex (ACC) source activation during both tasks. Remarkably, although cooperation resulted in greater losses for the participants, the betrayal options generated greater fERN responses. ADHD subjects exhibited an absence of fERN modulation and reduced ACC activation during both tasks. ASD subjects exhibited normal fERN modulation during monetary choices and inverted fERN/ACC responses in social options than did controls. These results suggest that in neurotypicals, monetary losses and observed disloyal social decisions induced similar activity in the brain value system. In ADHD children, difficulties in reward processing affected early brain signatures of monetary and social decisions. Conversely, ASD children showed intact neural markers of value-related monetary mechanisms, but no brain modulation by prosociality in the social task. These results offer insight into the typical and atypical developments of neural correlates of monetary and social reward processing.

PMID:
27464551
PMCID:
PMC4964357
DOI:
10.1038/srep30588
[Indexed for MEDLINE]
Free PMC Article

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