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Int J Exp Pathol. 2016 Aug;97(4):351-356. doi: 10.1111/iep.12192. Epub 2016 Jul 28.

Novel murine tumour models depend on strain and route of inoculation.

Author information

1
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. graham_pharm@aliyun.com.
2
Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
3
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
4
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
5
School of Pharmacy, Harbin Medical University, Harbin, China.

Abstract

This study describes variations in tumour growth patterns which occur when changes in the routes of inoculation and mouse strain are used to introduce tumours into established murine model systems that are known to vary in location and aggression. Intraperitoneal, subcutaneous, intravenous and hydrodynamic inoculations of B16F10 cells were compared among CD-1, C57BL/6 and Balb/c mice. Most surprisingly, allogeneic tumour growth in Balb/c mice after intravenous and hydrodynamic inoculation of B16F10 cells was faster than tumour growth in the syngeneic C57BL/6 mice. These and other variations in the tumour growth patterns described here can help provide the researcher with more experimental control when planning to use the optimal tumour model for any particular study.

KEYWORDS:

B16F10; hydrodynamic injection; intravenous; lung metastasis; tumour growth; tumour location

PMID:
27464477
PMCID:
PMC5061759
DOI:
10.1111/iep.12192
[Indexed for MEDLINE]
Free PMC Article

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