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Pharmacogenomics. 2016 Aug;17(12):1327-38. doi: 10.2217/pgs-2016-0056. Epub 2016 Jul 27.

Genetic polymorphisms influence on the response to clopidogrel in peripheral artery disease patients following percutaneous transluminal angioplasty.

Author information

1
Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
2
Genomics Unit, Centre for Genomics & Oncological Research (GENYO), Pfizer University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain.
3
Bioinformatics Unit, Centre for Genomics & Oncological Research (GENYO), Pfizer University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain.
4
Department of Cardiology, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.
5
Department of Vascular Surgery, San Cecilio University Hospital, Institute for Biomedical Research, ibs.GRANADA, Spain.

Abstract

AIM:

To study the association of ABCB1 and CYP2C19 polymorphisms and the clopidogrel response in Spanish peripheral artery disease patients following percutaneous transluminal angioplasty (PTA) and to perform a meta-analysis.

MATERIALS & METHODS:

72 patients were recruited and 122 patients included in the meta-analysis. We evaluated the effect of ABCB1 3435 C>T, CYP2C19*2 and CYP2C19*3 and primary end point (restenosis/occlusion of the treated lesions) during 12 months after PTA.

RESULTS:

CYP2C19*2 and/or ABCB1 TT patients were associated with primary end point (OR: 5.00; 95% CI: 1.75-14.27). The meta-analysis confirmed the association of CYP2C19*2 and new atherothrombotic ischemic events (OR: 5.40; 95% CI: 2.30-12.70).

CONCLUSION:

The CYP2C19 and ABCB1 polymorphisms could be genetic markers of cardiovascular events in peripheral artery disease patients following PTA treated with clopidogrel.

KEYWORDS:

SNP; clopidogrel; percutaneous transluminal angioplasty; pharmacogenetics

PMID:
27464309
DOI:
10.2217/pgs-2016-0056
[Indexed for MEDLINE]

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