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Am J Reprod Immunol. 2016 Sep;76(3):205-11. doi: 10.1111/aji.12541. Epub 2016 Jul 27.

Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia.

He Y1, Xu B1, Song D2,3,4, Yu F2,3,4, Chen Q1, Zhao M2,3,4,5.

Author information

1
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
2
Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
3
Key laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
4
Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing, China.
5
Peking-Tsinghua Center for Life Sciences, Beijing, China.

Abstract

PROBLEM:

To investigate the expression of complement activation factors in plasma of patients with early/late-onset severe pre-eclampsia.

METHODS:

A case-control study was performed. The study group consisted of 30 cases of early-onset severe pre-eclampsia (EOSPE) and 30 cases of late-onset severe pre-eclampsia (LOSPE). Thirty cases were selected as the early-onset control group (E-control) and 30 as the late-onset control group (L-control). ELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, and MAC in the maternal peripheral circulation.

RESULTS:

The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in EOSPE (all P<.01) and LOSPE (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.

CONCLUSION:

Abnormal activation of the complement system exists in the maternal circulation of patients with early- and late-onset severe pre-eclampsia. In patients complicated with LOSPE, the complement system was activated through both the classical and alternative pathways, while in EOSPE, the complement system was activated mainly through the alternative pathway.

KEYWORDS:

alternative pathway; complement activation; pre-eclampsia

PMID:
27461873
DOI:
10.1111/aji.12541
[Indexed for MEDLINE]

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