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Adv Mater. 2016 Oct;28(40):8861-8891. doi: 10.1002/adma.201601908. Epub 2016 Jul 27.

Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials.

Author information

1
Leibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany. freudenberg@ipfdd.de.
2
Department of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
3
Department of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA. kiick@udel.edu.
4
Department of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA. kiick@udel.edu.
5
Delaware Biotechnology Institute, 15 Innovation Way, Newark, DE, 19711, USA. kiick@udel.edu.
6
Leibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany. werner@ipfdd.de.
7
Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Fetcherstraße 105, 01307, Dresden, Germany. werner@ipfdd.de.

Abstract

Glycosaminoglycans (GAGs) govern important functional characteristics of the extracellular matrix (ECM) in living tissues. Incorporation of GAGs into biomaterials opens up new routes for the presentation of signaling molecules, providing control over development, homeostasis, inflammation, and tumor formation and progression. Recent approaches to GAG-based materials are reviewed, highlighting the formation of modular, tunable biohybrid hydrogels by covalent and non-covalent conjugation schemes, including both theory-driven design concepts and advanced processing technologies. Examples of the application of the resulting materials in biomedical studies are provided. For perspective, solid-phase and chemoenzymatic oligosaccharide synthesis methods for GAG-derived motifs, rational and high-throughput design strategies for GAG-based materials, and the utilization of the factor-scavenging characteristics of GAGs are highlighted.

KEYWORDS:

biomaterials; cell-instructive; glycosaminoglycans; growth factors; hydrogels

PMID:
27461855
PMCID:
PMC5152626
DOI:
10.1002/adma.201601908
[Indexed for MEDLINE]
Free PMC Article

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