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Trends Neurosci. 2016 Sep;39(9):581-586. doi: 10.1016/j.tins.2016.07.001. Epub 2016 Jul 25.

How Do Meningeal Lymphatic Vessels Drain the CNS?

Raper D#1,2, Louveau A#1,3, Kipnis J1,3.

Author information

1
Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
2
Department of Neurosurgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
3
Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
#
Contributed equally

Abstract

The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more clearly delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells, and macromolecules from the central nervous system (CNS) to the draining deep cervical lymph nodes. However, the exact localization of the meningeal lymphatic vasculature and the path of drainage from the cerebrospinal fluid (CSF) to the lymphatics remain poorly understood. Here, we discuss the potential differences between peripheral and CNS lymphatic vessels and examine the purported mechanisms of CNS lymphatic drainage, along with how these may fit into established patterns of CSF flow.

PMID:
27460561
PMCID:
PMC5002390
DOI:
10.1016/j.tins.2016.07.001
[Indexed for MEDLINE]
Free PMC Article

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