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Neurobiol Aging. 2016 Sep;45:64-75. doi: 10.1016/j.neurobiolaging.2016.05.005. Epub 2016 May 14.

Spatial training promotes short-term survival and neuron-like differentiation of newborn cells in Aβ1-42-injected rats.

Author information

1
Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Medicine Vocational and Technical School of Wuhan University, Wuhan, P. R. China.
2
Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Department of Pathology, Hubei University of Chinese Medicine, Wuhan, P. R. China.
3
Wuhan Pu Ai Hospital, Huazhong University of Science and Technology, Wuhan, P. R. China.
4
Department of Laboratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
5
Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Department of Basic Medicine, Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu Province, P. R. China.
6
Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
7
Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, P. R. China.
8
Department of Pathophysiology, Key Laboratory of Neurological Diseases of Chinese Ministry of Education, the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, P. R. China. Electronic address: liugp111@mail.hust.edu.cn.

Abstract

Neurogenesis plays a role in hippocampus-dependent learning and impaired neurogenesis may correlate with cognitive deficits in Alzheimer's disease. Spatial training influences the production and fate of newborn cells in hippocampus of normal animals, whereas the effects on neurogenesis in Alzheimer-like animal are not reported until now. Here, for the first time, we investigated the effect of Morris water maze training on proliferation, survival, apoptosis, migration, and differentiation of newborn cells in β-amyloid-treated Alzheimer-like rats. We found that spatial training could preserve a short-term survival of newborn cells generated before training, during the early phase, and the late phase of training. However, the training had no effect on the long-term survival of mature newborn cells generated at previously mentioned 3 different phases. We also demonstrated that spatial training promoted newborn cell differentiation preferentially to the neuron direction. These findings suggest a time-independent neurogenesis induced by spatial training, which may be indicative for the cognitive stimulation in Alzheimer's disease therapy.

KEYWORDS:

Alzheimer's disease; Hippocampus; Morris water maze; Neurogenesis; Spatial training

[Indexed for MEDLINE]

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