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Biomed Pharmacother. 2016 Oct;83:584-592. doi: 10.1016/j.biopha.2016.07.024. Epub 2016 Jul 25.

Protective effect of grape seed and skin extract against diabetes-induced oxidative stress and renal dysfunction in virgin and pregnant rat.

Author information

1
University of Carthage, Faculty of Sciences of Bizerte, 7021 Jarzouna, Tunisia; Laboratory of Bioactives Substances, Center of Biotechnology of Borj Cedria, BP 901, 2050 Hammam Lif, Tunisia.
2
University of Carthage, Faculty of Sciences of Bizerte, 7021 Jarzouna, Tunisia; Laboratory of Bioactives Substances, Center of Biotechnology of Borj Cedria, BP 901, 2050 Hammam Lif, Tunisia. Electronic address: charradi3@yahoo.com.
3
Laboratory of Bioactives Substances, Center of Biotechnology of Borj Cedria, BP 901, 2050 Hammam Lif, Tunisia.

Abstract

The present work deal with the effect of alloxan-induced diabetes on kidney oxidative stress and dysfunction of virgin and pregnant rat as well as the protection that may be afforded by high dosage GSSE (4g/kg) treatment. Diabetes affected negatively several kidney function parameters as creatinemia, uremia, uricemia and proteinuria without affecting kidney index. Diabetes also induced an oxidative stress characterized by increased lipid and protein oxidation, a drop in antioxidant enzyme defenses as catalase, superoxide-dismutase, glutathione-peroxidase, an alteration in transition metals as free iron, copper, selenium and associated enzymes and an increase in calpain and acetyl-cholinesterase activities. Tremendously, GSSE treatment protected efficiently against all the deleterious effects of diabetes-induced kidney dysfunction in both virgin and pregnant animals. High dosage GSSE is a safe and potent anti-oxidant that may be further tested in clinical trials for the long-term preservation of kidney function especially in multiple pregnancies.

KEYWORDS:

Diabetes; Grape seed and skin extract; Kidney protection; Oxidative stress; Rat

PMID:
27459114
DOI:
10.1016/j.biopha.2016.07.024
[Indexed for MEDLINE]

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