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Dev Cell. 2016 Jul 25;38(2):126-8. doi: 10.1016/j.devcel.2016.07.006.

Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.

Author information

1
F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
2
F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: beth.stevens@childrens.harvard.edu.

Abstract

Microglia are the primary phagocytes of the central nervous system. They eliminate excess functional connections between neurons to sculpt neuronal circuits during development and throughout adulthood. Understanding how microglia recognize and prune synapses during development is providing insight into synapse loss and dysfunction in disease.

PMID:
27459063
DOI:
10.1016/j.devcel.2016.07.006
[Indexed for MEDLINE]
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