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Oncotarget. 2016 Aug 23;7(34):54771-54781. doi: 10.18632/oncotarget.10754.

Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population.

Liu M1,2,3, Li B1,2, Guo W4, Zhang X1,2, Chen Z1,2, Li J1,2, Yan M1,2, Chen C1,2, Jin T1,2.

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School of Life Sciences, Northwest University, Xi'an 710069, China.
National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Inner Mongolia Medical University, Inner Mongolia, Hohhot 010050, China.


We investigated the associations between single nucleotide polymorphisms (SNPs) in the testis-specific Y-encoded-like protein 6 (TSPYL6) gene and breast cancer (BC) susceptibility in the Han Chinese population. A total of 183 BC patients and 195 healthy women were included in the study. Six SNPs in TSPYL6 were genotyped and the association with BC risk analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with BC susceptibility. Rs11896604 was associated with a decreased risk of BC based on dominant and genotype models. Rs843706 was associated with an increased risk of BC based on a recessive model. Rs11125529 was associated with decreased BC susceptibility based on a genotype model. Finally, rs843711 inversely correlated with clinical stage III/IV BC. Our findings reveal a significant association between SNPs in the TSPYL6 gene and BC risk in a Han Chinese population.


TSPYL6; association study; breast cancer; single nucleotide polymorphism

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