Send to

Choose Destination
Shock. 2017 Jan;47(1S Suppl 1):47-51.

Corticosteroids in Severe Sepsis and Septic Shock: A Concise Review.

Author information

*D'Or Institute for Reasearch and Education, Rio de Janeiro, Brazil †PostGraduate Program in Internal Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil ‡Polyvalent Intensive Care Unit, Hospital de Sao Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal §NOVA Medical School, CEDOC, New University of Lisbon, Lisbon, Portugal.


For decades, corticosteroids are proposed as adjuvant therapies for severe infections. Despite mounting evidence from randomized controlled trials, there is still an intense debate regarding the role of systemic low-dose corticosteroids as a part of the treatment of septic shock. In the present article, we review the current literature and detail aspects on the pathophysiologic rationale, the current evidence, actual practice, and future directions on this topic.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center