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Curr Opin Neurobiol. 2016 Aug;39:152-63. doi: 10.1016/j.conb.2016.06.006. Epub 2016 Jul 22.

Imaging of neuronal mitochondria in situ.

Author information

1
Institute of Neuronal Cell Biology, Technische Universität München, Munich, Germany. Electronic address: g.b.plucinska@uu.nl.
2
Institute of Neuronal Cell Biology, Technische Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Center for Integrated Protein Science, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Electronic address: thomas.misgeld@tum.de.

Abstract

Neuronal mitochondria are receiving a rapidly increasing level of attention. This is to a significant part due to the ability to visualize neuronal mitochondria in novel ways, especially in vivo. Such an approach allows studying neuronal mitochondria in an intact tissue context, during different developmental states and in various genetic backgrounds and disease conditions. Hence, in vivo imaging of mitochondria in the nervous system can reveal aspects of the 'mitochondrial life cycle' in neurons that hitherto have remained obscure or could only be inferred indirectly. In this survey of the current literature, we review the new insights that have emerged from studies using mitochondrial imaging in intact neural preparations ranging from worms to mice.

PMID:
27454347
DOI:
10.1016/j.conb.2016.06.006
[Indexed for MEDLINE]

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