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Toxicol Mech Methods. 2016 Sep;26(7):493-500. Epub 2016 Jul 25.

The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty.

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a The Ministry of Health, Keçiören Training and Research Hospital, Pediatric Endocrinology Clinics , Ankara , Turkey.
b Department of Pharmaceutical Toxicology , Faculty of Pharmacy, Hacettepe University , Ankara , Turkey , and.
c Department of Pediatrics , Division of Endocrinology, Yıldırım Beyazıt University , Ankara , Turkey.


Exposure to environmental chemicals can affect genetic and epigenetic molecular pathways and may cause altered growth and development. Among those exposures, endocrine-disrupting chemicals (EDCs) are of particular concern as humans are abundantly exposed to these chemicals by various means in every period of life. Several well-known environmental chemicals, including phthalates and bisphenol A (BPA), are classified as EDCs. These EDCs are suggested to play roles in early onset of puberty in girls. The aim of this study is to determine plasma phthalate (di(2-ethylhexyl)phthalate [DEHP] and its main metabolite mono(2-ethylhexyl)phthalate [MEHP]) and urinary BPA levels in girls with idiopathic central precocious puberty (CPP) and peripheral precocious puberty (PPP). This study was performed on newly diagnosed idiopathic central precocious puberty (CPP) patients (n = 42) and peripheral precocious puberty (PPP) (n = 42) patients, who were admitted to Keçiören Training and Research Hospital, Clinic of Pediatric Endocrinology between August 2012 and -July 2013. Nonobese healthy girls (n = 50) were used as the control group. Urinary BPA levels were not statistically different in control, PPP and CPP groups (medians 10.91, 10.63 and 10.15 μg/g creatinine, respectively; p > 0.05). Plasma DEHP levels were significantly higher in PPP group when compared to control. Plasma MEHP levels were not significantly different in control and PPP groups (p > 0.05). However, in CPP group, both plasma DEHP and MEHP levels were significantly higher than control and PPP groups. This study showed that phthalates might play a role in the occurence of CPP in girls.


Bisphenol A; central precocios puberty; endocrine disrupting chemical; peripheral precocious puberty; phthalate

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