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Clin Chim Acta. 2016 Oct 1;461:19-24. doi: 10.1016/j.cca.2016.07.011. Epub 2016 Jul 20.

Increased IL-37 concentrations in patients with arterial calcification.

Author information

1
Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2
Department of Pathology, Puren Hospital, Wuhan University of Science and Technology, Wuhan, China.
3
Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
4
Department of Ultrasound, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
5
Department of Orthopedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
6
Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. Electronic address: jqw124@163.com.

Abstract

BACKGROUND:

Our previous study indicates that IL-37 plays a critical role in both atherosclerosis and arterial calcification. However, whether IL-37 concentrations are significantly changed in patients with arterial calcification has not yet been investigated.

METHODS:

Anterior tibial arterial wall specimens were obtained from 8 patients with type 2 diabetes mellitus and 8 patients who experienced a traffic accident. IL-37 expression was measured by immunohistochemistry in the calcified and the normal samples. In addition, plasma IL-37 concentrations were measured in 75 patients with coronary artery calcification (CAC) and 50 patients without coronary artery calcification (NCAC).

RESULTS:

High concentrations of IL-37 were detected in calcified samples, whereas low concentrations of IL-37 were detected in the normal arteries. Macrophages and vascular smooth muscle cells were the main source of IL-37. Plasma IL-37 concentrations were significantly increased in CAC patients compared with NCAC patients. A correlation analysis showed that IL-37 was positively correlated with age, fasting glucose, alkaline phosphatase, IL-6, TNF-α, C-reactive protein and Agatston scores. Binary logistic regression analyses demonstrated that fasting glucose and IL-37 were independently associated with the presence of CAC.

CONCLUSIONS:

Increased IL-37 concentrations are associated with the onset of arterial calcification.

KEYWORDS:

Arterial calcification; IL-37; Inflammation

PMID:
27451144
DOI:
10.1016/j.cca.2016.07.011
[Indexed for MEDLINE]

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