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J Diet Suppl. 2017 Jan 2;14(1):65-75. doi: 10.1080/19390211.2016.1204404. Epub 2016 Jul 22.

Effect of Sesamin Supplementation on Glycemic Status, Inflammatory Markers, and Adiponectin Levels in Patients with Type 2 Diabetes Mellitus.

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a 1 Hyperlipidemia Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
b 2 Nutrition and Metabolic Diseases Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
c 3 Health Research Institute , Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
d 4 Faculty of Veterinary Medicine, Department of Food Hygiene , Shahid Chamran University of Ahvaz , Ahvaz , Iran.
e 5 Faculty of Public Health, Department of Biostatistics , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.



Sesamin is one of the most abundant lignans in sesame and has multiple functions and high values such as antioxidative effect and promoting-immunity function. The aim of this study was to evaluate the effects of sesamin supplementation on glycemic status, serum levels of inflammatory markers and adiponectinin patients with type 2 diabetes mellitus.


Forty-eight patients with type 2 diabetes participated in this double-blind, randomized, placebo-controlled clinical trial. Subjects were randomly assigned to two groups: intervention group (sesamin capsules; 200 mg/day, n = 24) and control group (placebo capsules; 200 mg/day starch, n = 24). Anthropometric indices and serum levels of fasting blood sugar (FBS), glycated hemoglobin (HbA1c), insulin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and adiponectin were assessed at the baseline and after 8 weeks.


Sesamin supplementation caused a significant reduction in FBS, HbA1C and TNF-α levels compared with the placebo (p < 0.05). Waist circumference, hip circumference, body adiposity index (BAI), FBS, HbA1c, TNF-α, and IL-6 levels were decreased, and adiponectin levels were increased significantly in the intervention group at the end of study (p < 0.05).


According to the beneficial effects of sesamin supplement on glycemic status and inflammatory factors, it may be considered as a supplementary therapeutic approach for diabetic patients. However, future investigations are needed in this field.


blood glucose; cytokines; diabetes; inflammation; sesamin

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