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Cir Esp. 2016 Oct;94(8):473-80. doi: 10.1016/j.ciresp.2016.05.010. Epub 2016 Jul 19.

Prognostic factors in resected pancreatic neuroendocrine tumours: Experience in 95 patients.

[Article in English, Spanish]

Author information

1
Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España. Electronic address: sbuenof@um.es.
2
Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
3
Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
4
Servicio de Radiodiagnóstico, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.

Abstract

INTRODUCTION:

The aim of this study was to analyze prognostic factors for survival and recurrence in patients with resected pancreatic neuroendocrine tumors (PNT).

METHODS:

Medical records of 95 patients with resected PNT were retrospectively reviewed. The variables studied were: age, sex, form of presentation (sporadic/familial tumors), functionality, type of tumor, localization, type of surgery, tumor size, multifocal tumors and recurrent rate. The new WHO classification (2010) was used.

RESULTS:

There were 45 men and 50 women. Mean age was 46.8 years. Regarding the mode of presentation, it was sporadic in 66 patients (69.8%) and 29 cases were familial neuroendocrine tumors (30.2%) in association with MEN 1 syndrome. The 59% of patients suffered from non-functional tumors and 41% were functional: 20 insulinoma, 16 gastrinoma, and 3 glucagonoma. Distal pancreatectomy was the most common surgical procedure, followed by tumor enucleation in 19 patients. According to the WHO classification, 59 patients had a PNT G1, 24 PNT G2 and 12 with a poorly-differentiated carcinoma, respectively. The 5-year survival in well-differentiated tumors was 100%, regardless of the functionality. Sporadic PNT are more commonly unifocal (P<0.001), associating liver metastasis. Survival and recurrence rates after a mean follow-up of 85.3 months were 65.8 and 24%, respectively.

CONCLUSIONS:

In our experience, WHO classification was an independent prognostic factor in PNT survival.

KEYWORDS:

Gastrinoma; Gastrinomas; Glucagonoma; Glucagonomas; Insulinoma; Insulinomas; Pancreas; Pancreatic neuroendocrine tumours; Pancreatic resection; Páncreas; Resección pancreática; Tumores neuroendocrinos del páncreas

PMID:
27450270
DOI:
10.1016/j.ciresp.2016.05.010
[Indexed for MEDLINE]

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