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Cell Tissue Res. 2017 Jan;367(1):125-140. doi: 10.1007/s00441-016-2463-1. Epub 2016 Jul 23.

Mitochondrial lipids in neurodegeneration.

Author information

1
Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria.
2
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, 106 91, Stockholm, Sweden.
3
Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria. sabrina.buettner@su.se.
4
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, 106 91, Stockholm, Sweden. sabrina.buettner@su.se.

Abstract

Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer's or Parkinson's disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies.

KEYWORDS:

Lipids; Mitochondria; Mitochondria-associated membranes; Mitochondrial dynamics; Neurodegeneration

PMID:
27449929
PMCID:
PMC5203858
DOI:
10.1007/s00441-016-2463-1
[Indexed for MEDLINE]
Free PMC Article

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