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Vaccine. 2017 Feb 15;35(7):1094-1100. doi: 10.1016/j.vaccine.2016.05.073. Epub 2016 Jul 20.

Personalized cancer vaccines: Targeting the cancer mutanome.

Author information

1
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States.
2
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, United States.
3
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: gillandersw@wudosis.wustl.edu.

Abstract

The development of next generation sequencing technologies has revolutionized our understanding of how specific genetic events contribute to cancer initiation and progression. Dramatic improvements in instrument design and efficiency, combined with significant cost reductions has permitted a systematic analysis of the mutational landscape in a variety of cancer types. At the same time, a detailed map of the cancer mutanome in individual cancers offers a unique opportunity to develop personalized cancer vaccine strategies targeting neoantigens. Recent studies in both preclinical models and human cancer patients demonstrate that neoantigens (1) are important targets following checkpoint inhibition therapy, (2) have been identified as the target of adoptive T cell therapies, and (3) can be successfully targeted with personalized vaccines. Taken together, these observations provide strong rationale for the clinical translation of personalized cancer vaccines.

KEYWORDS:

Cancer vaccine; Genome sequencing; Neoantigen; Personalized

PMID:
27449681
PMCID:
PMC5448976
DOI:
10.1016/j.vaccine.2016.05.073
[Indexed for MEDLINE]
Free PMC Article

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