Send to

Choose Destination
An Pediatr (Barc). 2017 Jul;87(1):26-33. doi: 10.1016/j.anpedi.2016.06.007. Epub 2016 Jul 20.

[Five steps to decreasing nosocomial infections in large immature premature infants: A quasi-experimental study].

[Article in Spanish]

Author information

Sección de Neonatología, Servicio de Pediatría, Hospital General Universitario Santa Lucía, Cartagena, Murcia, España. Electronic address:
Sección de Neonatología, Hospital General Universitario Santa Lucía, Cartagena, Murcia.
Sección de Neonatología, Servicio de Pediatría, Hospital General Universitario Santa Lucía, Cartagena, Murcia, España.



An evaluation is made of the impact of a series of five interventions on the incidence of hospital-related infections in a level iii neonatal unit.


Quasi-experimental, pre-post intervention study, which included preterm infants weighing 1,500g at birth or delivered at <32 weeks gestation, admitted in the 12 months before and after the measures were implemented (January 2014). The measures consisted of: optimising hand washing, following a protocol for insertion and handling of central intravenous catheters, encouraging breastfeeding; applying a protocol for rational antibiotic use, and establishing a surveillance system for multi-resistant bacteria. The primary endpoint was to assess the incidence of hospital-acquired infections before and after implementing the interventions.


Thirty-three matched patients were included in each period. There was an incidence of 8.7 and 2.7 hospital-related infections/1,000 hospital stay days in the pre- and post-intervention periods, respectively (P<.05). Additionally, patients in the treatment group showed a statistically-significant decrease in days on mechanical ventilation, use of blood products, and vasoactive drugs.


The strategy, based on implementing five specific measures in a unit with a high rate of hospital-related infections, proved effective in reducing their incidence. This reduction could contribute to lowering the use of mechanical ventilation, blood products, and vasoactive drugs.


Breastfeeding; Catheter-associated infections; Estrategias para disminuir las infecciones; Infecciones asociadas a catéter; Infección relacionada con la asistencia sanitaria; Lactancia materna; Neonato prematuro; Nosocomial infection; Preterm neonate; Strategies to reduce infections

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Ediciones Doyma, S.L.
Loading ...
Support Center