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Chem Biodivers. 2016 Dec;13(12):1685-1690. doi: 10.1002/cbdv.201600123. Epub 2016 Nov 21.

Four New Kaurane Diterpenoids from the Chinese Liverwort Jungermannia comata Nees.

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State Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology, School of Life Sciences, Shandong University, Shanda Nanlu 27, Jinan, 250100, P. R. China.
Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
Shandong Institute for Food and Drug Control, No. 2749 Xinluo Road, New and High-tech Developing Zone, Jinan, 250101, P. R. China.


In our continuing program to find new bioactive compounds from the Chinese liverworts, four new kaurane-type diterpenoids, (6β)-kaur-16-ene-6,9-diol (1), (6β,12β)-kaur-16-ene-6,9,12-triol (2), (6β)-kaur-16-ene-5,6,9-triol (3), and kaur-16-ene-9,19-diol (4), have been isolated from the Chinese liverwort Jungermannia comata Nees. Five known kaurane-type diterpenoids (5 - 9) and four known trachylobane-type diterpenoids (10 - 13) were also obtained. The structures of the new compounds were established unequivocally on the basis of spectroscopic data. The absolute configuration of compound 1 was established by comparing experimental and calculated electronic circular dichroism spectra.


Jungermannia comata ; Electronic circular dichroism; Kaurane-type diterpenoids

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