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Chem Biodivers. 2016 Dec;13(12):1685-1690. doi: 10.1002/cbdv.201600123. Epub 2016 Nov 21.

Four New Kaurane Diterpenoids from the Chinese Liverwort Jungermannia comata Nees.

Author information

1
State Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology, School of Life Sciences, Shandong University, Shanda Nanlu 27, Jinan, 250100, P. R. China.
2
Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
3
Shandong Institute for Food and Drug Control, No. 2749 Xinluo Road, New and High-tech Developing Zone, Jinan, 250101, P. R. China.

Abstract

In our continuing program to find new bioactive compounds from the Chinese liverworts, four new kaurane-type diterpenoids, (6β)-kaur-16-ene-6,9-diol (1), (6β,12β)-kaur-16-ene-6,9,12-triol (2), (6β)-kaur-16-ene-5,6,9-triol (3), and kaur-16-ene-9,19-diol (4), have been isolated from the Chinese liverwort Jungermannia comata Nees. Five known kaurane-type diterpenoids (5 - 9) and four known trachylobane-type diterpenoids (10 - 13) were also obtained. The structures of the new compounds were established unequivocally on the basis of spectroscopic data. The absolute configuration of compound 1 was established by comparing experimental and calculated electronic circular dichroism spectra.

KEYWORDS:

Jungermannia comata ; Electronic circular dichroism; Kaurane-type diterpenoids

PMID:
27448440
DOI:
10.1002/cbdv.201600123
[Indexed for MEDLINE]

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