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Genomics. 1989 May;4(4):552-9.

Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.

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  • 1Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.


Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).

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