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Int J Mol Sci. 2016 Jul 19;17(7). pii: E1163. doi: 10.3390/ijms17071163.

Current Stem Cell Biomarkers and Their Functional Mechanisms in Prostate Cancer.

Author information

1
The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. great_z0313@126.com.
2
Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA. great_z0313@126.com.
3
The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. 2005507098@163.com.
4
VIP Department of Beijing Hospital, Beijing 100730, China. luckyleileiaaa@sina.com.
5
Urology Department of Beijing Hospital, Beijing 100730, China. wjlspplaaa@sina.com.
6
The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. zou_qingsong@126.com.
7
Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA. wezhao@wakehealth.edu.
8
The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. jamesqfu@aliyun.com.
9
Department of Cancer Biology, Wake Forest University School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA. afang@nygenome.org.

Abstract

Currently there is little effective treatment available for castration resistant prostate cancer, which is responsible for the majority of prostate cancer related deaths. Emerging evidence suggested that cancer stem cells might play an important role in resistance to traditional cancer therapies, and the studies of cancer stem cells (including specific isolation and targeting on those cells) might benefit the discovery of novel treatment of prostate cancer, especially castration resistant disease. In this review, we summarized major biomarkers for prostate cancer stem cells, as well as their functional mechanisms and potential application in clinical diagnosis and treatment of patients.

KEYWORDS:

cancer stem cell; prostate cancer; stem cell biomarker

PMID:
27447616
PMCID:
PMC4964535
DOI:
10.3390/ijms17071163
[Indexed for MEDLINE]
Free PMC Article

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