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Psychiatry Res Neuroimaging. 2016 Aug 30;254:156-63. doi: 10.1016/j.pscychresns.2016.07.001. Epub 2016 Jul 6.

Altered brain functional networks in people with Internet gaming disorder: Evidence from resting-state fMRI.

Author information

1
Department of Psychology, Zhejiang Normal University, Jinhua, China.
2
Department of Psychology, University of Konstanz, Konstanz, Germany.
3
Center for Life Science, Peking University, Beijing, China.
4
Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
5
Department of Psychology, Zhejiang Normal University, Jinhua, China. Electronic address: dongguangheng@zjnu.edu.cn.

Abstract

Although numerous neuroimaging studies have detected structural and functional abnormality in specific brain regions and connections in subjects with Internet gaming disorder (IGD), the topological organization of the whole-brain network in IGD remain unclear. In this study, we applied graph theoretical analysis to explore the intrinsic topological properties of brain networks in Internet gaming disorder (IGD). 37 IGD subjects and 35 matched healthy control (HC) subjects underwent a resting-state functional magnetic resonance imaging scan. The functional networks were constructed by thresholding partial correlation matrices of 90 brain regions. Then we applied graph-based approaches to analysis their topological attributes, including small-worldness, nodal metrics, and efficiency. Both IGD and HC subjects show efficient and economic brain network, and small-world topology. Although there was no significant group difference in global topology metrics, the IGD subjects showed reduced regional centralities in the prefrontal cortex, left posterior cingulate cortex, right amygdala, and bilateral lingual gyrus, and increased functional connectivity in sensory-motor-related brain networks compared to the HC subjects. These results imply that people with IGD may be associated with functional network dysfunction, including impaired executive control and emotional management, but enhanced coordination among visual, sensorimotor, auditory and visuospatial systems.

KEYWORDS:

Emotional management; Executive control; Internet gaming disorder; Small-world

[Indexed for MEDLINE]

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