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Front Mol Biosci. 2016 Jun 27;3:25. doi: 10.3389/fmolb.2016.00025. eCollection 2016.

Potential Roles of Adropin in Central Nervous System: Review of Current Literature.

Author information

1
Department of Neurosurgery, Tehran University of Medical Sciences Tehran, Iran.
2
Department of Neurology, University of Tennessee Health Science Center Memphis, TN, USA.
3
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center Memphis, TN, USA.
4
Department of Neurology, University of Tennessee Health Science CenterMemphis, TN, USA; Biocomplexity Institute, Virginia Polytechnic Institute and State UniversityBlacksburg, VA, USA.

Abstract

Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.

KEYWORDS:

adropin; biomarker; cellular signaling pathways; neurodegenerative disease; neuroprotection; predictor; therapeutic

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