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Pain Res Manag. 2016;2016:2487924. doi: 10.1155/2016/2487924. Epub 2016 Mar 29.

Relationship between Neuropathic Pain and Obesity.

Author information

1
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
2
Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
3
Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
4
Department of Orthopaedic Surgery, Jichi University, Graduate School of Medicine, Tochigi, Japan.

Abstract

OBJECTIVES:

Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain. This was conducted to determine if obesity affects neuropathic pain, usually considered unrelated to the weight-load on the musculoskeletal system.

METHODS:

Using a cut-off body mass index value of 25, 44 patients with neuropathic pain were grouped into a "high-BMI" group and a "normal-BMI" group.

RESULTS:

The numeric rating scale of the high-BMI group was significantly higher than that of the normal-weight group (P < 0.05). The total NPSI scores were significantly higher (P < 0.01), and the paroxysmal pain and the negative symptoms were more serious in the high-BMI group than in the normal-BMI group. The high-BMI subjects also had significantly higher SF-MPQ scores (P < 0.05). However, both physical and mental health status on the SF-36 were comparable between the groups.

DISCUSSION:

Neuropathic pain that did not arise from musculoskeletal damage was higher in the high-BMI patients. Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation. These findings should have needed to be confirmed in future studies.

PMID:
27445603
PMCID:
PMC4904620
DOI:
10.1155/2016/2487924
[Indexed for MEDLINE]
Free PMC Article

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