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Cell Res. 2016 Aug;26(8):869-85. doi: 10.1038/cr.2016.86. Epub 2016 Jul 22.

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death.

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Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.


The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

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