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Br J Pharmacol. 2017 May;174(10):1025-1033. doi: 10.1111/bph.13559. Epub 2016 Aug 11.

Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells.

Author information

1
Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.
2
Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
3
Department of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
4
Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
5
Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada.
6
Department of Physiology and Center for Metabolism and Obesity Research, Johns Hopkins School of Medicine, Baltimore, MD, USA.
7
Department of Obstetrics, Gynecology & Reproductive Medicine, Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

Abstract

We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors.

LINKED ARTICLES:

This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc.

PMID:
27443788
PMCID:
PMC5406291
DOI:
10.1111/bph.13559
[Indexed for MEDLINE]
Free PMC Article

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