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Georgian Med News. 2016 Jun;(255):56-61.

GALECTIN-3 AS A PREDICTOR OF STATIN TREATMENT EFFICACY IN PATIENTS WITH MULTIPLE MYELOMA.

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1
Zaporozhye State Medical University, Zaporozhye, Ukraine.

Abstract

to investigate an interrelationship between pre-treatment galcetin-3 (Gal-3) level and one-year survival rate, cardiovascular events in subjects with multiple myeloma. Eighty nine subjects with full or partial remission of multiple myeloma were enrolled in the study. Patients were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=43) and a no statin group (n=46). Among the 43 patients in the statin group, 31 patients received 20mg/day atorvastatin and 12 patients received 40-mg/day atorvastatin. None of the patients had received any lipid-modulating medications, including statins or fibrates, before enrollment. Observation period was up to 1 year. Blood samples for biomarkers measurements were collected. ELISA method for measurements of circulating level of galectin-3, interleukin-6 and NT-pro-brain natriuretic peptide were used. Lipid lowering effect in statin user was associates with declined serum Gal-3 level, whereas in not statin users similar response was not appeared. No any changes in hemodynamics and other biomarkers between both cohorts were found. Univariate logistic regression had exhibited that galtctin-3 (odds ratio [OR] = 1.17; 95% CI = 1.07-1.29; P = 0.002), NT-pro-brain natriuretic peptide (OR=1.04; 95% CI=1.02-1.10; P<0.05) and statin therapy (OR=1.07; 95% CI = 1.02-1.11; P = 0.001) predicted one-year cumulative CV events. After adjustment on statin therapy, galectin-3 remained independent predictor one-year cumulative cardiovascular events (OR=1.08; 95% CI=1.06-1.11; P=0.001). When initial serum galectin-3 level has incorporated into prediction model, statin therapy was found as predictor for improving survival in multiple myeloma patients with elevated serum galectin-3 level (>14 ng/ml). Elevated pre-treatment galectin-3 level was found a powerful predictor of positive effect of statins on survival in patients with regression of multiple myeloma.

PMID:
27441537
[Indexed for MEDLINE]

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