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Int J Fertil Steril. 2016 Jul-Sep;10(2):239-44. Epub 2016 Jun 1.

Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats.

Author information

1
Neurophysiology Research Center, Shahed University, Tehran, Iran.
2
Department of Biochemistry, Faculty of Medicine, Shahed University, Tehran, Iran.
3
Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran.

Abstract

BACKGROUND:

Opioid consumption has been widely increasing across the globe; how- ever, it can cause adverse effects on the body. Morphine, an opioid, can reduce sex hor- mones and fertility. Withania somnifera (WS) is a traditional herb used to improve sexual activities. This study strives to investigate the effect of WS on sex hormones and gonado- tropins in addicted male rats.

MATERIALS AND METHODS:

In this experimental study, forty-eight male National Maritime Research Institute (NMRI) rats were randomly divided into four groups: i. Control group, ii. WS-treated control group, iii. Addicted group, and iv. WS-treated addicted group. Wa- ter-soluble morphine was given to rats for 21 days to induce addiction, concurrently the treated groups (2 and 4) also received WS plant-mixed pelleted food (6.25%). At the end of the treatment, the sex hormone and gonadotropin levels of the rats' sera were deter- mined in all the groups.

RESULTS:

Except for follicle-stimulating hormone (FSH), morphine reduced most of the gonadotropin and sex hormone levels. Whereas WS caused a considerable increase in the hormones in the treated addicted group, there was only a slight increase in the treated control group.

CONCLUSION:

WS increased sex hormones and gonadotropins-especially testosterone, es- trogen, and luteinizing hormone-in the addicted male rats and even increased the proges- terone level, a stimulant of most sex hormones in addicted male rats.

KEYWORDS:

Estrogen; Gonadotropins; Morphine; Testosterone; Withania somnifera

PMID:
27441058
PMCID:
PMC4948077

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