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Asia Pac J Clin Nutr. 2016;25(3):487-96. doi: 10.6133/apjcn.092015.06.

Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation.

Author information

1
Department of Medical Nutrition Therapy, Chonbuk National University, Jeonju, Jeonbuk, Republic of Korea.
2
Healthcare Claims and Management Incorporation, Jeonju, Jeonbuk, Republic of Korea.
3
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk, Republic of Korea.
4
Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea.
5
Research Group of Nutrition and Metabolism, Korea Food Research Institute, Seongnam, Gyonggi, Republic of Korea.
6
Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea. Email: soowan@jbnu.ac.kr.

Abstract

in English, Chinese

BACKGROUND AND OBJECTIVES:

Constipation affects up to 20% of the world's population. The aim of this study was to investigate whether supplementation with Ficus carica paste could be used to treat constipation in Korean subjects with functional constipation.

METHODS AND STUDY DESIGN:

We conducted a randomized, double-blind, placebo-controlled trial. Subjects with functional constipation were orally supplemented with either F. carica paste (n=40) or placebo (n=40) for 8 weeks. We measured the efficacy and safety of F. carica paste. Primary outcomes (colon transit time) and secondary outcomes (questionnaire related to defecation) were compared before and after the 8-week intervention period.

RESULTS:

F. carica paste supplementation was associated with a significant reduction in colon transit time and a significant improvement in stool type and abdominal discomfort compared with the placebo. Blood parameters and clinical findings for organ toxicity remained within normal ranges.

CONCLUSION:

These results suggest that F. carica paste may have beneficial effects in subjects suffering from constipation.

PMID:
27440682
DOI:
10.6133/apjcn.092015.06
[Indexed for MEDLINE]
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