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IUCrJ. 2016 Jun 27;3(Pt 4):228-9. doi: 10.1107/S2052252516010204. eCollection 2016 Jul 1.

Imaging enzyme kinetics at atomic resolution.

Author information

1
Physics, Arizona State University , Rural Rd, Tempe, 85287-1504, USA.
2
Hauptman-Woodward Medical Research Institute , 700 Ellicott Street, Buffalo, NY 14203-1101, USA.

Abstract

Serial crystallography at a synchrotron has been used to obtain time-resolved atomic resolution density maps of enzyme catalysis in copper nitrite reductase. Similar XFEL studies, intended to out-run radiation damage, will also soon appear.

KEYWORDS:

catalysis; denitrification; enzyme mechanism; radiation damage; radiolysis; serial crystallography; synchrotron radiation

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