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Infect Agent Cancer. 2016 Jul 19;11:34. doi: 10.1186/s13027-016-0077-6. eCollection 2016.

Expression of evolutionarily novel genes in tumors.

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The Biomedical Center and Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.


The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new functions beneficial to organisms. It is suggested to consider the expression of evolutionarily young or novel genes in tumors as a new biological phenomenon, a phenomenon of TSEEN (tumor specifically expressed, evolutionarily novel) genes.

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