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Curr Psychiatry Rep. 2016 Sep;18(9):81. doi: 10.1007/s11920-016-0719-9.

The Impact of Traumatic Brain Injury on the Aging Brain.

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The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Section of Neurosurgery, The University of Chicago Pritzker School of Medicine, MC 3026, J341, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.
Department of Neurosurgery, NorthShore University Health System, The University of Chicago Pritzker School of Medicine, Evanston, IL, USA.


Traumatic brain injury (TBI) has come to the forefront of both the scientific and popular culture. Specifically, sports-related concussions or mild TBI (mTBI) has become the center of scientific scrutiny with a large amount of research focusing on the long-term sequela of this type of injury. As the populace continues to age, the impact of TBI on the aging brain will become clearer. Currently, reports have come to light that link TBI to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, as well as certain psychiatric diseases. Whether these associations are causations, however, is yet to be determined. Other long-term sequelae, such as chronic traumatic encephalopathy (CTE), appear to be associated with repetitive injuries. Going forward, as we gain better understanding of the pathophysiological process involved in TBI and subclinical head traumas, and individual traits that influence susceptibility to neurocognitive diseases, a clearer, more comprehensive understanding of the connection between brain injury and resultant disease processes in the aging brain will become evident.


Aging; Chronic traumatic encephalopathy; Cognitive impairment; Concussion; Mild traumatic brain injury; Neurodegenerative disease; Traumatic brain injury

[Indexed for MEDLINE]

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