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BMC Cancer. 2016 Jul 18;16:494. doi: 10.1186/s12885-016-2515-7.

Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients.

Author information

1
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. fee.klupp@med.uni-heidelberg.de.
2
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
3
Department of Visceral, Thoracic and Vascular Surgery, University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
4
National Center for Tumor diseases, Medical Oncology and Internal medicine VI, Tissue Imaging and Analysis Center, Bioquant, University of Heidelberg, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.

Abstract

BACKGROUND:

Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases which are involved in angiogenesis, tumor invasion and metastatic formation. Up to date, the prognostic relevance of MMPs in serum of patients with colon cancer remains unknown. Thus, we wanted to assess an expression pattern of MMPs in a homogenous cohort of colon cancer patients to assess their potential as prognostic biomarkers.

METHODS:

Differences in the expression pattern of MMP7, MMP10 and MMP12 in 78 serum specimens of patients with an adenocarcinoma of the colon and serum specimens of a healthy control group were assessed using Luminex-100 technologies. Subsequently, we correlated these results with histopathological and clinical data of the patients.

RESULTS:

Luminex based expression analysis revealed a significant overexpression of MMP7 and an overexpression of MMP10 and MMP12 in the sera of colon cancer patients compared to the healthy control group. Patients with vascular invasion showed a significantly higher MMP12 expression than V0-staged patients. Moreover overexpression of MMP7, MMP10 and MMP12 in colon cancer patients´ sera displayed a significantly impaired overall survival. Multivariate analysis revealed high MMP10 serum levels to be an independent adverse prognostic marker in colon cancer patients.

CONCLUSIONS:

Expression patterns of MMP7, MMP10 and MMP12 in colon cancer patients´ sera are different compared to serum specimens of healthy individuals. Furthermore, overexpression of MMP7, MMP10 and MMP12 in colon cancer patients´ sera correlates with a dismal prognosis and may help to stratify patients into different risk groups.

KEYWORDS:

Colon cancer; MMP; Prognostic marker; Serum; Survival

PMID:
27431388
PMCID:
PMC4950722
DOI:
10.1186/s12885-016-2515-7
[Indexed for MEDLINE]
Free PMC Article

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