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Cancers (Basel). 2016 Jul 15;8(7). pii: E67. doi: 10.3390/cancers8070067.

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling.

Author information

1
Laboratory of Neuro-Oncology, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 12, Zagreb 10000, Croatia. nina@mef.hr.
2
Department of Biology, School of Medicine, University of Zagreb, Salata 3, Zagreb 10000, Croatia. nina@mef.hr.
3
Laboratory of Neuro-Oncology, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 12, Zagreb 10000, Croatia. anja.kafka@mef.hr.
4
Department of Biology, School of Medicine, University of Zagreb, Salata 3, Zagreb 10000, Croatia. anja.kafka@mef.hr.
5
Department of Pathology & Laboratory Medicine, University of California, Davis, Medical Center 4400 V Street, Sacramento, CA 95817, USA. mlechpammer@ucdavis.edu.

Abstract

Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the brain and the spinal cord. Most meningiomas have benign clinical behaviour and are classified as grade I by World Health Organization (WHO). However, up to 20% histologically classified as atypical (grade II) or anaplastic (grade III) are associated with higher recurrent rate and have overall less favourable clinical outcome. Recently, there is emerging evidence that multiple signalling pathways including Wnt pathway contribute to the formation and growth of meningiomas. In the review we present the synopsis on meningioma histopathology and genetics and discuss our research regarding Wnt in meningioma. Epithelial-to-mesenchymal transition, a process in which Wnt signalling plays an important role, is shortly discussed.

KEYWORDS:

APC; AXIN1; E-cadherin; Wnt signalling; beta-catenin; meningioma; meningioma genetics; p53

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