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AIDS. 2016 Sep 24;30(15):2299-302. doi: 10.1097/QAD.0000000000001195.

Polyfunctional HIV-specific T cells in Post-Treatment Controllers.

Author information

1
aINSERM U1135 CIMI bSorbonne Universités, UPMC Univ Paris 06, CIMI, Paris cInfectious and Tropical Diseases Department, Regional Hospital Center, Orléans dUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris eFaculté de Médecine, Université Paris Descartes, Sorbonne Paris-Cité fLaboratoire de Virologie, AP-HP, Hôpital Necker Enfants-Malades gDépartement d'Immunologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.

Abstract

To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4 T cells, which might contribute to the posttreatment control of HIV.

PMID:
27428742
DOI:
10.1097/QAD.0000000000001195
[Indexed for MEDLINE]

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